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Swelling and redness in an extremity are hallmark signs of peripheral thrombophlebitis. This condition arises due to inflammation of the vein, often in association with a blood clot. The inflammatory process leads to increased blood flow to the area, which causes the typical redness. Additionally, the accumulation of fluid in the tissues contributes to swelling, making these symptoms the most frequent and visible indicators of the condition.

While intense pain during movement may occur, it is not as universally present as swelling and redness. Heat in the surrounding tissue can accompany thrombophlebitis but is less frequently noted as a primary symptom. Weakness in the affected limb may also be experienced in some cases; however, it is not a direct or common symptom of peripheral thrombophlebitis compared to swelling and redness. Thus, these latter features are critical in recognizing and diagnosing the condition accurately.